Abstract: Lipreading or visually recognizing speech from the mouth movements of a speaker is a challenging and mentally taxing task. Unfortunately, multiple medical conditions force people to depend on this skill in their day-to-day lives for essential communication. Patients suffering from ‘Amyotrophic Lateral Sclerosis’ (ALS) often lose muscle control, consequently their ability to generate speech and communicate via lip movements. Existing large datasets do not focus on medical patients or curate personalized vocabulary relevant to an individual. Collecting large-scale dataset of a patient, needed to train modern data-hungry deep learning models is however, extremely challenging. In this work, we propose a personalized network to lipread an ALS patient using only one-shot examples. We depend on synthetically generated lip movements to augment the one-shot scenario. A Variational Encoder based domain adaptation technique is used to bridge the real-synthetic domain gap. Our approach significantly improves and achieves high top-5 accuracy with 83.2% accuracy compared to 62.6% achieved by comparable methods for the patient. Apart from evaluating our approach on the ALS patient, we also extend it to people with hearing impairment relying extensively on lip movements to communicate.